Ecology, Evolution and Engineering of Host-Associated Microbiomes

The realization that microbial communities, associated with virtually all multicellular organisms, have tremendous impact on their hosts’ health and development is considered one of the most important scientific discoveries in the last decade. Our research focuses on the ecology, evolution and engineering of host-associated microbial communities. Through novel experimental and computational approaches, we aim to unravel the complexity of microbial worlds in new dimensions and achieve targeted microbiome engineering.

Microbiome ecology

1) between-host heterogeneity: what are the key factors underlying the personalized response of host-associated microbiomes?

2) within-host heterogeneity: what are the principles governing the spatial organization of host-associated microbiomes?

Microbiome evolution

Do multiple strains co-exist in host environments? If so, how does functional diversity at the strain level shape the evolution of host-associated microbiomes?

Microbiome engineering

1) targeted engineering: can we precisely engineer host-associated microbiomes at the community level and at the genomic level?

2) improve host health